PRP – Growth Factors Therapy

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temps de mise à jour : 2018-01-20 17:32:00
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About PRP

Platelets’ (thrombocytes) healing properties are well known: they act as an intermediary that instigates the healing process in wounds or scars.  Similarly, platelets actively assist in the regeneration of cells.  Platelets contain an abundance of bioactive proteins (growth factors) and cytokines.  Through a process known as degranulation, these elements are released, attracting macrophages, mesenchymal stem cells and osteoblasts, which in turn are triggered promoting the removal of necrotic and degenerated tissue as well as contributing towards tissue regeneration and repair.

Autologous or Platelet-Rich Plasma is a substance (plasma) obtained and isolated following the centrifugation of blood.  PRP is activated with DNA activators (thrombin) and enriched with calcium ions (e.g. calcium chloride).

In hairloss, the intradermal application of plasma containing large amount of platelets, not only fortifies the hair follicle, thus ensuring its longevity and potency, but also reinvigorates dormant hair follicles and stimulates the growth of new hair.  When combined with hair transplantation, PRP promotes and enhances tissue repair, preserving and enhancing hair follicle viability.



PRP was initially developed in the 1970s.  Back in those days PRP went under names such as fibrin glue, platelet gel etc.  1987 is the year that PRP was first used after an open heart operation.  In the decades that follow, the medical community not only has recognized its enormous potential but as of the present moment application of PRP in numerous fields has been well documented.  It’s not so long ago the usefulness of PRP has been noted in the field of hair loss.

Suitable Patients:

In general, every healthy individual between 18 and 80 years of age can benefit from PRP; nevertheless, people who are dealing with the following conditions

●cancer and/or undergoing chemotherapy, ●chronic or acute infections, ●fever, ●sepsis, ●severe metabolic and/or system disorder, ●skin disease, ●anti coagulation therapies, ●chronic liver problems, ●recent use of corticosteroids, ● alopecia areata (controversial), ●autoimmune diseases (i.e. lupus, multiple sclerosis or scleroderma), ●pregnancy and breastfeeding, ●allergy to local anesthesia are cautioned against the treatment!

PRP is strongly recommended in situations that involve Androgenetic Alopecia, in Alopecia Areata, for Hair Transplant and as a preventative measure against hair loss.



Only specialized physicians who previously have been trained are permitted to execute PRP procedure.

The procedure lasts approximately one hour.  Hygiene and safety is closely observed and monitored throughout the procedure.  PRP can be and is used in conjunction with other conservative hair loss treatments (i.e. minoxidil), or with DHI’s Direct Hair Implantation.  When used alongside a hair transplant procedure, PRP is applied to both the donor and recipient areas, mainly to enhance the development of recently implanted hairs in the recipient area and to spurt the regeneration of partially transected follicles in the donor area.

When PRP sessions are properly planned out and executed in a timely fashion they inhibit further loss of hair.

The procedure of a session

Step 1:  The doctor takes a small amount of blood from the patient, the amount is determined given the patient’s hair loss problem.  The amount of blood does not exceed 50 cc (50 ml).

Step 2:  The blood is then set in motion within a centrifuge apparatus, allowing the platelet enriched plasma to be separated from the rest of the blood components.  During this process there is a two to fourfold increase in the platelet                        content from the normal 150000m3-350000m3 (avg. 250000m3) to 1000000m3.

Step 3:  Centrifuged plasma is inserted in a syringe or mesotherapy gun.

Step 4:  Local anesthesia is applied in the area of interest, where hair loss is apparent and hair is sparse.

Step 5:  Calcium ions are then added so as to activate the platelets contained in the PRP.

Step 6:  Multiple intradermal injections are made on the scalp.

During the first year, three or so sessions are held which are repeated every 4 to 6 weeks.  Thereafter, sessions are scheduled once or twice a year for maintenance of the results.


Benefits when PRP is solely used:

PRP is regarded as a safe treatment with no contraindications.  Since one’s own blood is used during any PRP session, potential problems of rejection and allergies are practically eliminated.  Similarly, down time is minimal with no side effects, and results are immediate.

Benefits when PRP is used in hair transplant:

  1. Accelerates and enhances the healing process

  2. Reduces trauma, inflammation and erythema (redness)

  3. Reduces the formation of crust

  4. Reduces patients discomfort

  5. Scientists have observed acceleration in the growth and the revascularization of the follicles, while a noticeable increase in the size of follicles per unit.

are and accepting on the possibilities of improving their appearance through cosmetic surgery, laser therapies, cryoablation, and many other newer treatment modalities. Microneedling or dermarolling therapy is one of the emerging techniques in the cosmetic era.

There are more research, clinical trials and case study done to investigate the efficacy of microneedling therapy in treating various skin disorders such post-acne scarring, various types of scars, alopecia, and many other skin marks that are unsightly to look at. It is quite amazing to see how microneedling evolve through the years.

It is said that dermarolling therapy is the “new thing” when it comes to cosmetic rejuvenation. In here, you will learn where dermarolling stand as a therapy and how it is being applied cosmetically.

What is Dermarolling Therapy?

If you are new to dermarolling therapy, then let us define first what it is?

Dermarolling therapy is also called as Microneedling therapy and or Percutaneous Collagen Induction Therapy.  It is a safe, very simple, minimally invasive and effective therapeutic technique.  Initially, it was introduced for skin rejuvenation and gain wide acceptance worldwide. Due to the success of dermarolling therapy, a lot of research has been done determining if it can also be used in other skin conditions.

Over the years, the treatment evolved and it is now being used to treat acne, acne scars, burn or post-traumatic scar, drug delivery, stretch marks, and many other indications. For more than 10 years, a lot of innovation has been made even to the device itself.  The technique is now being combined with other surgical procedures to provide better outcome.

More so, this procedure is a safe technique particularly for those with dark skin types. It is quite a challenge to treat dark-skinned individuals because of the higher risk of post-inflammatory pigmentation. They are also more prone to have damage in the epidermis.

Dermarolling therapy has been used for wide array of indications. In fact, there are many clinical trials that provide evidence for its usefulness. It is a stand-alone technique which can also be combined with other treatment modalities like platelet rich plasma, chemical peeling, and subcision, radiofrequency, lasers and punch elevation. It is also used in conjunction with other topical formulation, thus, enhancing its penetration and action.

Skin Rejuvenation? Is it the Key to Younger Looking Skin?

As mentioned, dermarolling was used initially for skin rejuvenation. Even famous celebrities post their pictures on the internet showing how they used microneeding to improve their skin’s appearance.

So how does, dermarolling therapy works in skin rejuvenation? Dermarolling leads to reorganization of old collagen fibers and lay down new collagen, capillaries and elastin that leads to skin tightening.  There is a significant increase in the levels of collagen type I, III, and VII.

After 6 microneedling sessions with 2 week intervals, it was observed that there are newly synthesized tropoelastin and collagen from baseline. The percutaneous collagen induction leads to a youthful appearance of the skin by reducing wrinkles and fine lines. It also reduce pore size, provides more elasticity and suppleness of the skin.

The effect is further enhanced when the procedure is combined with a topical anti-aging serum like Tretinoin and Vitamin C. There are also clinical trials where dermarolling therapy is combined with human embryonic stem cells which are derived from the endothelial precursor cell conditioned medium and it has shown significant reduction in pigmentation and wrinkles.

Large multicenter trials have also studied fractional microneedling radiofrequency and it was found out that it is effective in reducing wrinkles.

How is Fractional Microneeding Radiofrequency Being Done?  Is it Effective for Skin Rejuvenation?

Microneedle Fractional Radiofrequency is a recently developed and minimally invasive technique used for skin rejuvenation. This method delivers radiofrequency energy directly into your skin using microneedles. More so, the use of growth factors for skin rejuvenation is an emerging treatment for anti-aging.

A number of studies have evaluated the safety and efficacy of microneedle fractional radiofrequency. There are also studies where it examined its synergistic effect with stem cell conditioned medium which are composed of large number of cytokines and growth factors.

Trials have concluded that microneedlle fractional radiofrequency is an effective and safe skin rejuvenation method. Studies have shown that better results may be expected when the method is combined with a stem cell conditioned medium.

Multiple Microneedling Session for Facial Rejuvenation

Dermarolling or percutaneous collagen induction therapy is a new treatment modality used for skin rejuvenation, scar remodelling and skin tightening. It offers an effective and simple approach for photo aged skin with minimal disruption of the epidermis. It limits adverse effects by minimizing downtime.

Why Dermarolling Therapy is the Next New Thing?

Patients having wrinkles or unwanted scars have several therapeutic options on how to improve the appearance of their skin. The available treatment modalities that offer desirable results are usually overtly invasive and or entail higher risk of undesirable side effects.

Dermarolling therapy has emerged as non-ablative alternative for managing patients who have some concern on aesthetic changes that result from aging, disease or from injury.

Although, dermarolling is a relatively new treatment modality in dermatology, it has been touted for broad range of applications. The significant increase for minimally invasive procedures has been reported for the past several years. The studies suggest that dermarolling may occupy a specific niche for patients who wants and desire measurable clinical results from treatment that offers little to no recovery.

Dermarolling therapy has a bright future. People want a treatment modality that is effective yet affordable. More so, the minimally invasive technique of microneeding is also an added advantage.  Most of the clinical trials in microneedling showed promising results.